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Challenges of applying multicellular tumor spheroids in preclinical phase

Khamis T, Hegazy AA, El-Fatah SSA, Abdelfattah ER, Abdelfattah MMM, Fericean LM, Arisha AH (2023) Hesperidin mitigates cyclophosphamide-induced testicular dysfunction via altering the hypothalamic pituitary gonadal axis and testicular steroidogenesis, inflammation, and apoptosis in male rats

Researchers study this compound to understand how blocking NNMT activity affects related metabolic pathways at the cellular level

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The latter one, the humectant property, is surprising and comes from the unique property of ricinoleic acid (the dominant fatty acid in castor oil) having an extra water-loving -OH group on its otherwise oil-loving fatty chain